Higenamine-d4-1-hydrochloride-Norcoclaurine-d-sub-4-sub-1-hydrochloride-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Higenamine-d4-1hydrochloride

Cat.No.:HY-N2037AS1

Synonyms:Norcoclaurine-d-1hydrochloride;Demethyl-Coclaurine-d-1

44

hydrochloride

分⼦式:C₁₆H₁₄D₄ClNO₃

分⼦量:311.8

作⽤靶点:Isotope-LabeledCompounds;ROSKinase;Apoptosis;MDM-

2/p53;MAP3K

作⽤通路:Others;ProteinTyrosineKinase/RTK;Apoptosis;MAPK/ERK

Pathway

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Higenamine-d4-1(Norcoclaurine-d4-1)hydrochloride是氘代标记的Higenamine(hydrochloride)。

Higenaminehydrochloride是⼀种可以从乌头毒草中分离得到的选择性的LSD1抑制剂(IC50=1.47μM)。

Higenaminehydrochloride具有抗炎、抗菌活性。Higenamine(Norcoclaurine)能通过ROS介导的PI3K/Akt

信号通路来减弱IL-1β引起的凋亡。Higenaminehydrochloride能保护脑细胞免受缺氧损伤。Higenamine

能够通过SMAD2/3途径促进⾻质疏松症的⾻形成。Higenaminehydrochloride可以⽤于癌症、炎症、⼼肾综

合征等疾病的研究[1][2][3][4][5][6]。

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019

Feb;53(2):211-216.

[2].FangY,etal.Discoveryofhigenamineasapotent,selectiveandcellu