JBJ-07-149-生命科学试剂-MCE.pdf

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JBJ-07-149

Cat.No.:HY-151048

CASNo.:2140807-58-3

分⼦式:C₂₈H₂₆N₆O₂S

分⼦量:510.61

作⽤靶点:EGFR

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性JBJ-07-149是EGFRL858R/T790M的抑制剂，IC50为1.1nM。JBJ-07-149抑制Ba/F3细胞增殖，在没有和有

Cetuximab(HY-P9905)联合使⽤的情况下，IC50分别为4.9μM和0.148μM。JBJ-07-149可以作为靶蛋⽩

配体⽤于合成DDC-01-163(HY-139997)。

IC50TargetEGFRL858R/T790M

1.1nM(IC50)

REFERENCES

[1].JangJ,etal.,Mutant-SelectiveAllostericEGFRDegradersareEffectiveAgainstaBroadRangeofDrug-ResistantMutations.Angew

ChemIntEdEngl.2020Aug17;59(34):14481-14489.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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