KP-6-生命科学试剂-MCE.pdf

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KP-6

Cat.No.:HY-P6441

CASNo.:2102414-23-1

分⼦式:C₁₅₉H₂₃₂N₄₆O₄₄

分⼦量:3491.83

Sequence:Gln-Pro-Val-Val-Thr-Leu-Tyr-His-Trp-Asp-Leu-Pro-Gln-Arg-Le

u-Gln-Asp-Ala-Tyr-Gly-Gly-Trp-Ala-Asn-Arg-Ala-Leu-Ala-Asp-

His

SequenceShortening:QPVVTLYHWDLPQRLQDAYGGWANRALADH

作⽤靶点:β-catenin;Wnt

作⽤通路:StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性KP-6是⼀种多肽，是⼀种Wnt/β-catenin信号抑制剂。KP-6抑制TGF-β并阻断体内⾄关重要的快速纤维化

信号通路。KP-6抑制肾组织损伤和肾纤维化，逆转慢性肾病（CKD）的病程。

REFERENCES

[1].YouhuaLiu,etal.PurposesofthemicromoleculepolypeptideKP6inthemedicineforpreparingtreatmentCKD.CN106822865A.

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