新指南-固定复方制剂.pptVIP

早期血压控制能否改善预后？VALUE:Systolicbloodpressure

instudyJuliusSetal.Lancet.June2004;363.mmHg01.02.03.04.01244823461218303642546066Months(orfinalvisit)5.0DifferenceinSBPBetweenValsartanandAmlodipine–1.0Valsartan

(N=7649)Amlodipine

(N=7596)135140145150155mmHgMonths(orfinalvisit)SittingSBPbyTimeandTreatmentGroupBaseline12448234612183036425460664.0mmHg早期降压有效的患者获益更多WeberMAetal.Lancet.2004;363:2047–49.致死/非致死性心脏事件致死/非致死性脑卒中全因死亡心肌梗死心衰住院0.40.60.81.01.21.4早期降压有效患者*(n=9336)非早期降压有效患者(n=5663)95%CI