Cyclic-YCDGFYACYMDV-生命科学试剂-MCE.pdf

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Cyclic(YCDGFYACYMDV)

Cat.No.:HY-P10793

CASNo.:535959-77-4

分⼦式:C₆₅H₈₂N₁₂O₂₀S₃

分⼦量:1447.61

Sequence:Tyr-Cys-Asp-Gly-Phe-Tyr-Ala-Cys-Tyr-Met-Asp-Val(Disulfide

bridge:Cys2-Cys8)

SequenceShortening:YCDGFYACYMDV(Disulfidebridge:Cys2-Cys8)

作⽤靶点:EGFR;Apoptosis

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Cyclic(YCDGFYACYMDV)是⼀种HER2信号传导抑制剂，具有抗癌活性。Cyclic(YCDGFYACYMDV)在⽔溶液

中⾃组装成纳⽶颗粒，通过与癌细胞上的HER2靶向结合转化为纳⽶原纤维，来破坏HER2⼆聚化和随后的下

游信号事件，从⽽导致癌细胞凋亡(Apoptosis)。这种对HER2乳腺癌的抑制作⽤在⼩⿏异种移植模型中被证明

有效[1]。

IC50TargetHER2

REFERENCES

[1].ZhangL,etal.TransformablepeptidenanoparticlesarrestHER2signallingandcausecancercelldeathinvivo.NatNanotechnol.2020

Feb;15(2):145-153.

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