Emavusertib-phosphate-CA-4948-phosphate-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Emavusertibphosphate

Cat.No.:HY-135317F

CASNo.:2376399-38-9

Synonyms:CA-4948phosphate

分⼦式:C₂₄H₂₈N₇O₉P

分⼦量:589.49

作⽤靶点:IRAK;FLT3;NF-κB;MyD88;Apoptosis

作⽤通路:Immunology/Inflammation;ProteinTyrosineKinase/RTK;NF-κ

B;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Emavusertibphosphate(CA-4948phosphate)是Emavusertib(HY-135317)的磷酸盐形式。Emavusertib

phosphate是⼝服有效的IRAK4(IC50=57nM)和FLT3抑制剂。Emavusertibphosphate可抑制NF-κB和

MyD88信号通路，减少促炎细胞因⼦（如IL-6和IL-10）的产⽣，从⽽表现出抗炎和对癌细胞的抗增殖活性

，诱导细胞凋亡(apoptosis)。Emavusertibphosphate在⼩⿏模型中表现出抗肿瘤活性。

客户使⽤本产品发表的科研⽂献

•Blood.2023May12;blood.2022018718.

•FrontImmunol.09March2021.

•CurrIssuesMolBiol.2024Mar29,46(4),2946-2960.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].WieseMD,etal.InvestigationalIRAK-4inhibitorsforthetreatmentofrheumatoidarthritis.ExpertOpinInvestigDrugs.2020Apr17:1-8.

[2].GuidettiF,etal.TargetingIRAK4withEmavusertibinLymphomaModelswithSecondaryResistancetoPI3KandBTKInhibitors.JClin

Med.2023Jan4;12(2):399.

[3].ParrondoRD,etal.IRAK-4inhibition:emavusertibforthetreatmentoflymphoidandmye