P315V3-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

P315V3

Cat.No.:HY-P10872

分⼦式:C₂₄₁H₄₀₇N₅₉O₈₀S

分⼦量:5443.22

Sequence:Val-Asp-Leu-Gly-Asp-Ile-Ser-Gly-Ile-Asn-Ala-Ser-Val-Val-Asn-Ile-G

ln-Lys-Glu-Ile-Asp-Arg-Leu-Asn-Glu-Val-Ala-Lys-Asn-Leu-Asn-Glu-

Ser-Leu-Ile-Asp-Leu-Gln-Glu-Leu-Gly-Ser-Gly-Ser-Gly-Cys-PEG4-

(CH2CO2)-Cholesterol

SequenceVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGSGSGC-

Shortening:PEG4-(CH2CO2)-Cholesterol

作⽤靶点:SARS-CoV

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsinthe

CertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性P315V3是⼀种冠状病毒(coronavirus)泛型抑制剂，可抑制SARS-CoV-2原型PT、Delta、BA.1和BA.4毒株

，IC50分别为10.9、8.9、8.6和2.7nM。P315V3在Vero细胞中表现出细胞毒性，CC50为4.3μM。

P315V3在⼩⿏模型中表现出抗感染活性。

REFERENCES

[1].WuL,etal.,Apan-coronaviruspeptideinhibitorpreventsSARS-CoV-2infectioninmicebyintranasaldelivery.SciChinaLifeSci.2023

Oct;66(10):2201-2213.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.