Mutant-IDH1-IN-3-生命科学试剂-MCE.pdf

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MutantIDH1-IN-3

Cat.No.:HY-100476

CASNo.:1648909-73-2

分⼦式:C₂₂H₃₀N₄O

分⼦量:366.5

作⽤靶点:IsocitrateDehydrogenase(IDH)

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MutantIDH1-IN-3(Compound1)是⼀种针对突变型异柠檬酸脱氢酶1(IDH1)的选择性变构抑制剂，对

R132HIDH1的IC50为13nM。MutantIDH1-IN-3能够抑制细胞中D-2羟基戊⼆酸(2HG)产⽣。Mutant

IDH1-IN-3可⽤于肿瘤的研究。

IC50TargetR132HIDH1

13nM(IC50)

REFERENCES

[1].DengG,etal.Selectiveinhibitionofmutantisocitratedehydrogenase1(IDH1)viadisruptionofametalbindingnetworkbyanallosteric

smallmolecule.JBiolChem.2015Jan9;290(2):762-74.

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