CDK9-autophagic-degrader-1-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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CDK9autophagicdegrader1

Cat.No.:HY-168896

CASNo.:3066836-42-5

分⼦式:C₃₄H₃₉N₇O₄S₂

分⼦量:673.85

作⽤靶点:CDK;ATTECs

作⽤通路:CellCycle/DNADamage;Autophagy;PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CDK9autophagicdegrader1(Compound28)是⼀种ATTEC降解剂，可⽤于降解CDK9，还能影响与其相关

的CyclinT1的⽔平。CDK9autophagicdegrader1在100nM时表现出超过80％的CDK9抑制率。(粉⾊:

LC3B配体(HY-168897);⿊⾊:连接⼦(HY-W017758);蓝⾊:靶蛋⽩配体(HY-10008);连接⼦+靶蛋⽩配体(HY-

168898))。

IC50TargetCDK9

REFERENCES

[1].YanpingZeng,etal.Discoveryof2,4-quinazolinedionederivativesasLC3Brecruitersinthefacilitationofproteincomplexdegradations.

EurJMedChem.2025Jan19:287:117293.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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