Endoxifen-Standard-生命科学试剂-MCE.pdf

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Endoxifen(Standard)

Cat.No.:HY-18719ER

CASNo.:110025-28-0

分⼦式:C₂₅H₂₇NO₂

分⼦量:373.49

作⽤靶点:CytochromeP450;EstrogenReceptor/ERR;DrugMetabolite;

Parasite

作⽤通路:MetabolicEnzyme/Protease;VitaminDRelated/Nuclear

Receptor;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Endoxifen(Standard)是Endoxifen的分析标准品。本产品⽤于研究及分析应⽤。Endoxifen是Tamoxifen的

关键活性代谢物，与雌激素受体(estrogenreceptor)有较⾼的亲和⼒和特异性，同时也能抑制芳⾹酶的活性。

Endoxifen有⽤于乳腺癌研究的潜⼒。

IC50TargetEstrogenReceptor[1][2].

REFERENCES

[1].GoetzMP,etal.Tamoxifen,endoxifen,andCYP2D6:therulesforevaluatingapredictivefactor.Oncology(WillistonPark).2009

Dec;23(14):1233-4,1236.

[2].WuX,etal.Thetamoxifenmetabolite,endoxifen,isapotentantiestrogenthattargetsestrogenreceptoralphafordegradationinbreast

cancercells.CancerRes.2009Mar1;69(5):1722-7.

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