Retapamulin-Standard-生命科学试剂-MCE.pdf

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Retapamulin(Standard)

Cat.No.:HY-17010R

CASNo.:224452-66-8

分⼦式:C₃₀H₄₇NO₄S

分⼦量:517.76

作⽤靶点:Bacterial;Antibiotic

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Retapamulin(Standard)是Retapamulin的分析标准品。本产品⽤于研究及分析应⽤。Retapamulin(SB-

275833)是⼀种外⽤抗⽣素，能与⾦黄⾊葡萄球菌和⼤肠杆菌核糖体结合，Kd为3nM。Retapamulin可⽤于

特异性⽪炎和前列腺癌的研究[1][2][8]。

REFERENCES

[1].KircikLH.Efficacyandtolerabilityofretapamulin1%ointmentforthetreatmentofinfectedatopicdermatitis:apilotstudy.JDrugs

Dermatol.2012Jul;11(7):858-60.

[2].YanK,etal.Biochemicalcharacterizationoftheinteractionsofthenovelpleuromutilinderivativeretapamulinwithbacterialribosomes.

AntimicrobAgentsChemother.2006Nov;50(11):3875-81.

[3].CandelFJ,etal.Invitroactivityofretapamulinagainstlinezolidandmethicillin-resistantStaphylococcusaureusisolates.RevEsp

Quimioter.2011Sep;24(3):127-30.

[4].Pérez-TralleroE,etal.Invitroactivitiesofretapamulinand16otherantimicrobialagentsagainstrecentlyobtainedStreptococcus

pyogenesisolates.AntimicrobAgentsChemother.2011May;55(5):2406-8.

[5].JonesRN,etal.Activityofretapamulin(SB-275833),anovelpleuromutilin,againstsel