INK4C-IN-2-生命科学试剂-MCE.pdfVIP

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INK4C-IN-2

Cat.No.:HY-108420

CASNo.:6314-70-1

分⼦式:C₁₃H₁₇NO₄S

分⼦量:283.34

作⽤靶点:CDK

作⽤通路:CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

溶解性数据

体外实验DMSO:250mg/mL(882.33mM;Needultrasonic)

Mass

Solvent

1mg5mg10mg

Concentration

制备储备液1mM3.5293mL17.6466mL35.2933mL

5mM0.7059mL3.5293mL7.0587mL

10mM0.3529mL1.7647mL3.5293mL

BIOLOGICALACTIVITY

⽣物活性INK4C-IN-2(Compound40)是INK4C（也称为p18）的抑制剂和CDK4/6的激活剂。INK4C-IN-2可增加⼩⿏

和⼈类造⾎⼲细胞(HSCs)的数量和扩增能⼒，EC50为5.21nM，促进HSCs的⾃我更新和多向分化。INK4C-

IN-2可在⼩⿏⾻髓移植模型中提⾼HSCs的扩增和长期造⾎重建能⼒[1]。

客户使⽤本产品发表的科研⽂献

•CellDeathDis.2019Mar20;10(4):271.

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