Linaprazan-Standard-AZD0865-Standard-生命科学试剂-MCE.pdf

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Linaprazan(Standard)

Cat.No.:HY-100412R

CASNo.:248919-64-4

Synonyms:AZD0865(Standard)

分⼦式:C₂₁H₂₆N₄O₂

分⼦量:366.46

作⽤靶点:ProtonPump

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Linaprazan(Standard)是Linaprazan的分析标准品。本产品⽤于研究及分析应⽤。Linaprazan(AZD0865)能

够通过K+竞争约束抑制胃⾥H+,K+-ATPase，(IC50:1.0±0.2μM)，它对酸有很强的抑制作⽤。Linaprazan

(AZD0865)可⽤于研究反流性⾷管炎，具有⼝服有效性。

REFERENCES

[1].GeddaKetal.MechanismofactionofAZD0865,aK+-competitiveinhibitorofgastricH+,K+-ATPase.BiochemPharmacol.2007Jan

15;73(2):198-205.

[2].KahrilasPJetal.Arandomized,comparativestudyofthreedosesofAZD0865andesomeprazoleforhealingofrefluxesophagitis.Clin

GastroenterolHepatol.2007Dec;5(12):1385-91.

[3].XinyueZhang,etal.Absorption,distribution,metabolismandexcretionoflinaprazanglurateinrats.JPharmBiomedAnal.2024May

15:242:116012.

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