BU224-hydrochloride-Standard-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

BU224hydrochloride(Standard)

Cat.No.:HY-101170R

CASNo.:205437-64-5

分⼦式:C₁₂H₁₂ClN₃

分⼦量:233.7

作⽤靶点:ImidazolineReceptor;Apoptosis;TNFReceptor

作⽤通路:NeuronalSignaling;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BU224(hydrochloride)(Standard)是BU224(hydrochloride)的分析标准品。本产品⽤于研究及分析应⽤。

BU224hydrochloride是⼀种选择性⾼亲和⼒的咪唑啉imidazolineI2受体配体，Ki为2.1nM。BU224

hydrochloride有时被⽤作I2受体拮抗剂。BU224hydrochloride具有神经保护作⽤，具有抗炎、抗凋亡作⽤

。BU224hydrochloride可改善5XFAD⼩⿏的记忆，增⼤树突棘和减少Aβ诱导的NMDARs的变化。BU224

hydrochloride可⽤于阿尔茨海默病研究[1][2][3]。

IC50TargetKi:2.1nM(I2)[1]

REFERENCES

[1].MirzaeiN,etal.ImidazolineligandBU224reversescognitivedeficits,reducesmicrogliosisandenhancessynapticconnectivityina

mousemodelofAlzheimersdisease.BrJPharmacol.2021Feb;178(3):654-671.

[2].FinnDP,etal.Behavioral,neuroendocrineandneurochemicaleffectsoftheimidazolineI2receptorselectiveligandBU224innai