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Carbocisteine-13C3-1

Cat.No.:HY-D0205AS1

CASNo.:1391068-19-1

Synonyms:Carbocysteine-13C3-1

分⼦式:C₂₁₃C₃H₉NO₄S

分⼦量:182.17

作⽤靶点:Isotope-LabeledCompounds;Keap1-Nrf2;NF-κB;PERK;

Apoptosis

作⽤通路:Others;NF-κB;CellCycle/DNADamage;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Carbocisteine-13C3-1(Carbocysteine-13C3-1)是13C标记的Carbocisteine.Carbocisteine是⼀种具有⼝服

活性的粘液溶解剂。Carbocisteine可减轻NF-κBp65和ERK1/2的磷酸化。Carbocisteine调节Nrf2/HO-1和

NFκB相互作⽤。Carbocisteine抑制凋亡(Apoptosis)。Carbocisteine可⽤于慢性阻塞性肺疾病(COPD)的研

究[1][2][3][4][5][6][7][8][9][10][11][12][13]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].YagetaY,etal.Car