Decitabine-13C5-5-Aza-2-deoxycytidine-sup-13-sup-C-sub-5-sub-生命科学试剂-MCE.pdfVIP

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Decitabine-13C5

Cat.No.:HY-A0004S

Synonyms:5-Aza-2-deoxycytidine-13C;5-AZA-CdR-13C;NSC127716-13C

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5

分⼦式:C₃₁₃C₅H₁₀N₄O₄

分⼦量:231.15

作⽤靶点:Isotope-LabeledCompounds;DNAMethyltransferase;

NucleosideAntimetabolite/Analog;Apoptosis

作⽤通路:Others;Epigenetics;CellCycle/DNADamage;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Decitabine-13C5(5-Aza-2-deoxycytidine-13C5)是13C标记的Decitabine.Decitabine(5-Aza-2-

deoxycytidine)是⼀种具有⼝服活性的脱氧胞苷类似物抗代谢物(deoxycytidineanalogueantimetabolite)和

DNA甲基转移酶(DNAmethyltransferase)抑制剂。Decitabine代替DNA掺⼊胞嘧啶可以将DNA甲基转移酶

共价捕获到DNA中，从⽽导致对该酶的不可逆抑制。Decitabine诱导细胞G2/M阻滞和细胞凋亡(

apoptosis)，并具有有效的抗癌活性。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs