Everolimus-13C2-d4-RAD001-sup-13-sup-C-sub-2-sub-d-sub-4-sub-生命科学试剂-MCE.pdfVIP

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Everolimus-13C2,d4

Cat.No.:HY-10218S1

CASNo.:1661009-29-5

Synonyms:RAD001-13C,d;SDZ-RAD-13C,d

2424

分⼦式:C₅₁₁₃C₂H₇₉D₄NO₁₄

分⼦量:964.23

作⽤靶点:Isotope-LabeledCompounds;Bacterial;Autophagy;FKBP;

mTOR;Apoptosis

作⽤通路:Others;Anti-infection;Autophagy;Apoptosis;CellCycle/DNA

Damage;Immunology/Inflammation;PI3K/Akt/mTOR

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Everolimus-13C2,d4(RAD001-13C2,d4)是13C标记的Everolimus.Everolimus(RAD001)是⼀种雷帕霉素(

Rapamycin;HY-10219)的衍⽣物，也是⼀种有效的，选择性的和⼝服活性的mTOR1抑制剂。Everolimus与

FKBP-12结合可产⽣免疫抑制复合物。Everolimus抑制肿瘤细胞增殖并诱导细胞凋亡(apoptosis)和⾃噬(

autophagy)。Everolimus具有有效的免疫抑制和抗癌活性。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumS