C-021-Standard-生命科学试剂-MCE.pdf

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C-021(Standard)

Cat.No.:HY-103364R

CASNo.:864289-85-0

分⼦式:C₂₇H₄₁N₅O₂

分⼦量:467.65

作⽤靶点:CCR

作⽤通路:GPCR/GProtein;Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性C-021(Standard)是C-021的分析标准品。本产品⽤于研究及分析应⽤。C-021是有效的CC趋化因⼦受体4(

CCR4)拮抗剂。C-021有效抑制⼈和⼩⿏的功能趋化性，IC50分别为140nM和39nM。C-021以IC50为18

nM来有效阻⽌⼈CCL22衍⽣的[35S]GTPγS与受体结合。

REFERENCES

[1].YokoyamaK,etal.PotentandorallybioavailableCCR4antagonists:Synthesisandstructure-activityrelationshipstudyof2-

aminoquinazolines.BioorgMedChem.2009Jan1;17(1):64-73.

[2].MatthewMcMillin,etal.NeuronalCCL2isupregulatedduringhepaticencephalopathyandcontributestomicrogliaactivationand

neurologicaldecline.JNeuroinflammation.2014Jul10;11:121.

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