Biotin-13C5-Vitamin-B7-sup-13-sup-C-sub-5-sub-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Biotin-13C5

Cat.No.:HY-B0511S3

Synonyms:VitaminB7-13C;VitaminH-13C;D-Biotin-13C

555

分⼦式:C₅₁₃C₅H₈N₂O₃S

分⼦量:241.21

作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite

作⽤通路:Others;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Biotin-13C5(VitaminB7-13C5)是13C标记的Biotin.Biotin，即维⽣素B7，是⼈体五种羧化酶的辅酶，参与

脂肪酸、异亮氨酸和缬氨酸的合成，并参与糖异⽣。Biotin是细胞⽣长、脂肪酸产⽣以及脂肪和氨基酸代谢的

必需物质。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].Zempleni,etal.Biotinbiochemistryandhumanrequirements.JNutrBiochem,1999.10(3):p.128-38.

[3].Mock,D.M..Biotinstatus:whicharevalidindicatorsandhowdoweknow?JNutr,1999.129