CDK9-IN-37-生命科学试剂-MCE.pdf

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CDK9-IN-37

Cat.No.:HY-173481

分⼦式:C₂₀H₁₉FN₂O₄S₂

分⼦量:434.5

作⽤靶点:CDK

作⽤通路:CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CDK9-IN-37(Compound24)是⼀种CDK9抑制剂(EC50:5.5nM)，且对其他CDK亚型抑制较弱，表现出⾼选

择性。CDK9-IN-37对急性髓系⽩⾎病细胞MOLM-13具有显著的抗增殖活性(IC50:0.034μM)。CDK9-IN-37

通过抑制CDK9信号通路，降低RNAPIICTD(Ser2)磷酸化⽔平，下调抗凋亡蛋⽩McI-1，诱导细胞凋亡(

apoptosis)，并将细胞周期阻滞在G2/M期。CDK9-IN-37可⽤于急性髓系⽩⾎病(AML)的研究[1]。

IC50TargetCDK9

5.5nM(EC50)

REFERENCES

[1].ChenS,etal.Design,synthesisandbio-evaluationof2,5-disubstitutedthiazolederivativesforpotentialtreatmentofacutemyeloid

leukemiathroughtargetingCDK9.BioorgChem.2025Jun15;160:108436.

McePdfHeight

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