Eprenetapopt-GMP-APR-246-GMP-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Eprenetapopt(GMP)

Cat.No.:HY-19980G

CASNo.:5291-32-7

Synonyms:APR-246(GMP);PRIMA-1Met(GMP)

分⼦式:C₁₀H₁₇NO₃

分⼦量:199.25

作⽤靶点:MDM-2/p53;Apoptosis;Ferroptosis

作⽤通路:Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Eprenetapopt(GMP)(APR-246(GMP))是GMP级的Eprenetapopt(HY-19980)。Eprenetapopt(APR-246)是

同类⾸创的⼩分⼦，可恢复TP53突变细胞中的野⽣型p53功能。Eprenetapopt可引发肿瘤细胞凋亡。

Eprenetapopt还靶向硒蛋⽩硫氧还蛋⽩还原酶1(TrxR1)，它是细胞氧化还原平衡的关键调节因⼦[1][2][3]。

客户使⽤本产品发表的科研⽂献

•BoneRes.2023May29;11(1):28.

•SciAdv.2022Sep16;8(37):eabm9427.

•CellDeathDis.2024Nov12;15(11):820.

•CellDeathDis.2023Dec14;14(12):831.

•CellBiosci.2022Feb25;12(1):20.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].PengX,etal.APR-246/PRIMA-1METinhibitsthioredoxinreductase1andconvertstheenzymetoadedicatedNADPHoxidase.Cell

DeathDis.2013Oct24;4:e881

[2].StuberG,etal.PRIMA-1METinducesnucleolartranslocationofEpstein-Barrvirus-encodedEBNA-5protein.MolCancer.2009Mar

26;8:23.

[3].SallmanDA,etal.Eprenetapopt(APR-246)andAzacitidineinTP53-MutantMyelodysplasticSyndromes.JClinOncol.

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