多组分反应和串联反应.pptxVIP

第五章Multi-ComponentReactionsMulticomponentsreactions(MCRs)arethosereactionsinwhichthreeormorereactantscometogetherinasinglereactionvesseltoformanewproductwhichcontainsportionsofallthecomponentsMCRA+B+C….PConvergencyComplexityProductivitySelectivityAtomeconomyDiversity

一、多组分反应的历史

IvarKarlUgi(1930-2005),theinventorofthemostsignificantisocyanidebasedMCRs.

多组分反应涉及的反应机理Angew.Chem.Int.Ed.1998,37,2234离子机理异腈参与的多组分反应大多为离子机理。

自由基机理Angew.Chem.Int.Ed.2003,42,3490

3.周环反应机理TetrahedronLett.1998,29,5855

Angew.Chem.Int.Ed.1998,37,152混合机理自由基和负离子组合

金属催化的多组分反应

四、多组分反应展望HardlyafieldinorganicchemistryhasevolvedfasteroveronlyacoupleofyearsthanMCRs.However,theverylargeMCRspaceof1020isonlyexploredmarginally.FutureresearchintheareaofMCRswillincludethediscoveryanddesignofnovelMCRs,combinationsofMCRsandtraditionalreactions,experimentalimprovementsinsolid-andliquid-phase,enantio-anddiastereo-selectivevariations,andmoreandmoreapplicationsindrugdiscovery,materialscience,bioconjugates,andagrochemicalcompounds.

第六章串联反应新进展串联反应（Tandemreaction）串级反应(Cascadereaction)多米诺反应(Dominoreaction)连续反应(Sequentialreaction)Tandemreactions,inwhichmultiplereactionsarecombinedintoonesyntheticoperation,havebeenreportedextensivelyinthesyntheticchemistryliterature....

Angew.Chem.Int.Ed.2009,48,7064–7068

重排反应01自由基反应02Michael加成反应03过渡金属催化的反应04Fischer卡宾配合物的反应05周环反应06其他反应07