Lpathomab-LT3015-生命科学试剂-MCE.pdfVIP

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Lpathomab

Cat.No.:HY-P991310

CASNo.:1253114-37-2

Synonyms:LT3015;LT-3000

作⽤靶点:LPLReceptor

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Lpathomab(LT3015;LT-3000)是⼀种靶向LPA的⼈类IgG1单克隆抗体(mAb)。Lpathomab降低SKOV3细

胞中IL-8和IL-6细胞因⼦的释放，并阻断LPA触发的肿瘤细胞迁移。Lpathomab在Matrigel栓和CNV模型

中减少新⽣⾎管形成。Lpathomab在CCI⼩⿏模型中可抑制脑损伤。Lpathomab可⽤于脑损伤、卵巢癌、糖

尿病性神经病变和脊髓损伤的研究。推荐同型对照：HumanIgG1kappa，IsotypeControl(HY-P99001)[1]

[2]。

REFERENCES

[1].VisentinB,etal.Abstract#1247:InvitroandinvivoefficacyofLpathomab\#8482;,amonoclonalantibodydirectedagainst

lysophosphatidicacid(LPA),inovariancancermodels[J].CancerResearch,2009,69(9_Supplement):1247-1247.

[2].CrackPJ,etal.Anti-lysophosphatidicacidantibodiesimprovetraumaticbraininjuryoutcomes.JNeuroinflammation.2014Feb

27;11:37.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.