微针介导的纳米递送系统在经皮给药中的研究进展.pdfVIP

微针介导的纳米递送系统在经皮给药中的研究进展

陈瑶，麻忆静，曾露露，郑高利，尹丽娜，张雅雯(杭州医学院，杭州

310013)**

摘要：由于角质层的屏障作用，大多数药物的经皮渗透效率较低，导致经皮给药系统的应用受到很大的限制。微针

(microneedle，MNs)递药系统和纳米递药系统是目前透皮给药研究最为广泛的2种给药系统。MNs递药系统能在皮肤表面

形成微小通道以促进药物的渗透，能快速将纳米药物送至毛细血管参与全身循环，且不触及真皮层中的神经产生痛感；纳

米递药系统既能增加药物渗透，还可改善药物的药动学和药效学特征，提高生物利用度，并减轻不良反应。因此，MNs介

导的纳米递送系统作为一种经皮给药的新兴载体显示出了巨大的应用潜力与前景，受到了越来越广泛的关注。

关键词：微针；纳米递送系统；经皮给药系统

中图分类号：R94文献标志码：A文章编号：1007-7693(2025)12-2169-10

DOI:10.13748/ki.issn1007-7693

引用本文：陈瑶,

麻忆静,

曾露露,

等.

微针介导的纳米递送系统在经皮给药中的研究进展[J].

中国现代应用药学,

2025,

42(12):

2169-2178.

ResearchProgressofMicroneedle-mediatedNanodeliverySystemsinTransdermalDrugDelivery

**

CHEN

Yao,

MA

Yijing,

ZENG

Lulu,

ZHENG

Gaoli,

YIN

Lina,

ZHANG

Yawen(HangzhouMedicalCollege,

Hangzhou310013,China)

ABSTRACT:Due

to

the

effect

of

cuticle

barrier,

the

transdermal

penetration

efficiency

of

most

drugs

is

low.

Therefore,

the

application

of

transdermal

drug

delivery

system

is

greatly

limited.

Microneedle

drug

delivery

system

and

nanodelivery

system

are

the

two

most

widely

studied

transdermal

drug

delivery

systems.

The

microneedle

drug

delivery

system

can

form

tiny

channels

on

the

surface

of

the

skin

to

promote

drug

penetration,

and

can

quickly

send

nanodrugs

to

the

capillaries

to

participate

in

the

systemic

circulation

without

touching

the

nerves

in

the

dermis

to

cause

pain.

The

nanodelivery

system

not

only

enhances

drug

penetration,

but

also

improves

the

pharmacokinetic

and

pharmacodynamic

properties

of

drugs,

thereby

increasing

bioavailability,

while

minimizing

adverse

reactions.

As

a

novel

transdermal

drug

delivery

carrier,

microneedle-mediated

nanodelivery

system

has

shown

great

potential

and

promising

prospect,

attracting

widespread

attention

in

recent

research.

KEYWORDS:microneedle;

nanodelivery

system;

transdermal

drug

delivery

system

经皮给药系统是经皮肤吸收药物的一种新型前透皮给药研究最为广泛的