Candidusin-A-CHNQD-0803-生命科学试剂-MCE.pdfVIP

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CandidusinA

Cat.No.:HY-N16066

CASNo.:81474-59-1

Synonyms:CHNQD-0803

分⼦式:C₂₀H₁₆O₆

分⼦量:352.34

作⽤靶点:AMPK;Apoptosis;NF-κB;TNFReceptor

作⽤通路:Epigenetics;PI3K/Akt/mTOR;Apoptosis;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CandidusinA(CHNQD-0803)(Compound4)是⼀种AMPK激活剂，其KD为47.28nM。CandidusinA可从

海洋真菌Aspergilluscandidus中分离得到。CandidusinA对⼈前列腺癌细胞(22Rv1、PC-3和LNCaP细胞)

有细胞毒活性，并可诱导其凋亡(apoptosis)。CandidusinA可减少脂肪⽣成基因表达和脂肪沉积，负向调控

NF-κB-TNFα炎症轴以抑制炎症，并改善肝损伤和纤维化。CandidusinA可⽤于⾮酒精性脂肪性肝炎(NASH)

研究[1][2]。

REFERENCES

[1].YurchenkoAN,etal.MetabolitesofthemarinefungusAspergilluscandidusKMM4676associatedwithakurilcolonialascidian[J].

ChemistryofNaturalCompounds,2017,53(4):747-749.

[2].ChenJ,etal.Discoveryofanaturalsmall-moleculeAMP-activatedkinaseactivatorthatalleviatesnonalcoholicsteatohepatitis.MarLife

SciTechnol.2023Apr30;5(2):196-210.

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