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GEP44

Cat.No.:HY-P11043

分⼦式:C₂₃₃H₃₅₆N₆₈O₆₈

分⼦量:5197.73

Sequence:His-{d-Ser}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Tyr-Leu-

Glu-Glu-Glu-Ala-Val-Arg-Glu-Phe-Ile-Ala-Trp-Leu-Lys-Asn-Gly-

Gly-Pro-Ser-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-

NH2

SequenceH-{d-Ser}-

Shortening:QGTFTSDLSKYLEEEAVREFIAWLKNGGPSRHYLNLVTRQRY-

NH2

作⽤靶点:GLPReceptor;NeuropeptideYReceptor;Arrestin

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性GEP44是⼀种靶向胰⾼⾎糖素样肽1受体(GLP-1R)、神经肽Y1受体(Y1-R)和神经肽Y2受体(Y2-R)的肽偏向

的三重激动剂。GEP44通过抵消Y1-R和GLP-1R激动作⽤，诱导⼤⿏和⼈类胰岛中由Y1-R拮抗剂控制的、

GLP-1R依赖性的胰岛素分泌刺激。GEP44促进肌⾁组织中胰岛素⾮依赖性的Y1-R介导的葡萄糖摄取，并显著

降低饮⾷诱导的肥胖⼤⿏模型的⾷物摄⼊量和体重。GEP44可⽤于肥胖及2型糖尿病研究[1]。

IC50TargetNPYY2receptorNPYY1receptorArrestin-3/β-Arrestin2

34nM(IC50)