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NAB815

Cat.No.:HY-P11232

CASNo.:1969250-99-4

分⼦式:C₅₅H₉₄N₁₄O₁₄

分⼦量:1175.42

Sequence:Octanoic-{Dab}-Thr-{d-Thr}-{Dab}-{Dab}-{d-Phe}-Leu-{Abu}-{D

ab}-Thr(lactambridge:Dab4-Thr10)

SequenceShortening:Octanoic-{Dab}-T-{d-Thr}-{Dab}-{Dab}-{d-Phe}-L-{Abu}-{Dab}-

T(lactambridge:Dab4-Thr10)

作⽤靶点:Toll-likeReceptor(TLR);Bacterial

作⽤通路:Immunology/Inflammation;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NAB815是⼀种Stx2a(Kd=0.01μM)/TLR4相互作⽤的特异性抑制剂。NAB815抑制中性粒细胞/Stx2a相互

作⽤(IC50=0.057μg/mL)。NAB815抑制⽩细胞和⾎⼩板产⽣的含Stx2的细胞外囊泡(EV)的形成，并降低

其在细胞(Vero细胞)和动物模型(CD-1⼩⿏)中的毒性作⽤。NAB815降低⼤肠杆菌感染的⼩⿏肾脏、尿液和

膀胱中的细菌(bacterial)负荷。NAB815可⽤于溶⾎性尿毒症综合征(HUS)的研究。

体外研究NAB815(1nM,4h)inhibitstheformationofwhitebloodcell/plateletaggregatesbyStx2a[1].

NAB815(0.01-0.1μg/mL,4h)slightlyaffectstheviabilityofhumanleukocytesbuthasnoeffecton

erythrocytes,inhibitstheformationofplatelet-derivedandleukocyte-derivedpathogenicEVscontaining

Stx2a,impairstherecruitmentofcomplementfactorsinStx2-indu