1R-2R-Elpipodect-1R-2R-MK-8189-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

(1R,2R)-Elpipodect

Cat.No.:HY-153093A

CASNo.:1424378-99-3

Synonyms:(1R,2R)-MK-8189

分⼦式:C₁₉H₂₂N₆OS

分⼦量:382.48

作⽤靶点:Phosphodiesterase(PDE)

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(1R,2R)-Elpipodect((1R,2R)-MK-8189)是Elpipodect(HY-153093)的(1R,2R)型对映异构体。Elpipodect(MK-

8189)是⼀种⼝服有效的选择性PDE10A抑制剂，Ki值为29pM。Elpipodect可⽤于精神分裂症的研究。

IC50TargetPDE10A

29pM(Ki)

REFERENCES

[1].LaytonME,et,al.DiscoveryofMK-8189,aHighlyPotentandSelectivePDE10AInhibitorfortheTreatmentofSchizophrenia.JMed

Chem.2023Jan26;66(2):1157-1171.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1Master