1S-2S-3R-PLX-4545-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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(1S,2S,3R)-PLX-4545

Cat.No.:HY-159647B

CASNo.:2892066-42-9

分⼦式:C₂₈H₃₁N₃O₄

分⼦量:473.56

作⽤靶点:MolecularGlues;IKZFFamily

作⽤通路:PROTAC;Immunology/Inflammation

储存⽅式:Powder-20°C3years

4°C2years

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性(1S,2S,3R)-PLX-4545是PLX-4545(HY-159647)的(1S,2S,3R)型对映异构体。PLX-4545是⼀种具有⼝服活性

和选择性的基于cereblon的IKZF2(锌指转录因⼦Helios)分⼦胶(molecularglue)降解剂。PLX-4545可将免

疫抑制调节性T细胞重新编程为促炎效应T细胞，从⽽增强抗肿瘤免疫反应[1]。

IC50TargetIZKF2

REFERENCES

[1].HuangY,etal.PLX-4545,aselectiveIKZF2degrader,reprogramssuppressiveTregsleadingtotumorgrowthinhibitionand

combinationbenefitwithimmunecheckpointtherapy[J].CancerResearch,2025,85(8_Supplement_1):6380-6380.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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