BChE-p38-α-MAPK-IN-1-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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BChE/p38-αMAPK-IN-1

Cat.No.:HY-175655

CASNo.:3077831-11-6

分⼦式:C₂₆H₃₂F₂N₄O

分⼦量:454.56

作⽤靶点:p38MAPK;Cholinesterase(ChE);InterleukinRelated

作⽤通路:MAPK/ERKPathway;NeuronalSignaling;

Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BChE/p38-αMAPK-IN-1是⼀种选择性的双重抑制剂，针对hBChE(IC50=772nM)和p38αMAPK(IC50=

191nM)。BChE/p38-αMAPK-IN-1可减少细胞中促炎性细胞因⼦(IL-1β、IL-6、IL-8、TNF-α)的产⽣。

BChE/p38-αMAPK-IN-1能够改善Scopolamine(HY-N0296)诱导的认知障碍，同时缓解LPS(HY-D1056)诱

导的空间学习障碍，并在⼩⿏中发挥抗神经炎症作⽤。BChE/p38-αMAPK-IN-1可⽤于阿尔茨海默病(AD)的

研究[1]。

IC50Targetp38αMAPKhBCHE

191nM(IC50)772nM(IC50)

体外研究BChE/p38-αMAPK-IN-1(Compound95)showsinhibitorypotencyagainsthBChE(IC50=772nM)andp38α

MAPK(IC50=191nM)[1].

BChE/p38-αMAPK-IN-1(1-5μM,18h)reducestheproductionofpro-inflammatorycytokines(IL-1β,IL-6,IL-

8,TNF-α)andslightlyincreasesanti-inflammatorycytokineIL-12inPhytohemagglutinin(PHA)(HY-N7038)-

stimulated