Basivarsen-DYNE-101-oligomer-生命科学试剂-MCE.pdfVIP

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Basivarsen

Cat.No.:HY-177453

CASNo.:3028750-61-7

Synonyms:DYNE-101oligomer

分⼦式:C₂₂₈H₃₁₇N₇₀O₁₀₇P₁₆S₁₅

分⼦量:6726.91

作⽤靶点:Antibody-OligonucleotideConjugates(AOCs)

作⽤通路:Antibody-drugConjugate/ADCRelated

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Basivarsen(DYNE-101oligomer)由反义寡核苷酸和连接⼦(HY-177454)组成，靶向突变型I型肌营养不良蛋

⽩激酶(DMPK)的RNA进⾏RHaseH介导的降解，⽤于肌营养不良症1型(DM1)的研究。

REFERENCES

[1].WeedenT,PicarielloT,QuinnB,etal.FORCEplatformovercomesbarriersofoligonucleotidedeliverytomuscleandcorrectsmyotonic

dystrophyfeaturesinpreclinicalmodels.CommunMed(Lond).2025;5(1):22.

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