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WLBU2

Cat.No.:HY-P11085

CASNo.:847061-43-2

分⼦式:C₁₅₁H₂₆₀N₆₆O₂₅

分⼦量:3400.11

Sequence:Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-

Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg

SequenceShortening:RRWVRRVRRWVRRVVRVVRRWVRR

作⽤靶点:Bacterial

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性WLBU2是⼀种⼯程阳离⼦抗菌肽(eCAP)，可克服天然抗菌肽(AMPs)在环境中的敏感性问题。WLBU2表现出

快速杀菌作⽤，对多种⾰兰⽒阳性菌和阴性菌的MIC值≤l0μM(包括耐甲氧西林⾦黄⾊葡萄球菌、耐万古霉

素肠球菌、肺炎克雷伯菌、产⽓肠杆菌、阴沟肠杆菌、⼤肠埃希菌等)。WLBU2能阻⽌铜绿假单胞菌的⽣物膜

⽣长，在富含粘液、低pH和⾼盐浓度的环境仍能保持活性，且对⼈类呼吸道上⽪细胞⽆不良影响。WLBU2可

⽤于研究囊性纤维化(CF)与铜绿假单胞菌感染[1]。

体外研究WLBU2(5-90μM,24h(abioticsurface);10-100μM,5h(CFAECs))preventsabioticP.aeruginosabiofilms

onanabioticsurfaceandonhumancysticfibrosisairwayepithelialcells(CFAECs)[1].

WLBU2(50μM,5h)retainsbiofilmpreventionactivityinhighsalt(100mMNacl)andlowpH(6.5-7.0)

environmentsinCFAECs[1].

WLBU2(20μM,5h)showssynergisticeffectwhencombinedwithTobramycin(HY-B0441),ciprofloxacin

(HY-B0356),Ceftazidime(HY-B0593),andMerop