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Myeloidneosmpostcytotoxictherapy

Definition

Myeloidneosmspostcytotoxictherapy(MN-pCTs)includemyelodyssticneosms

(MDSs),myelodysstic/myeloproliferativeneosms(MDS/MPNs),andacutemyeloid

leukaemia(AML)thatariseinapatientwithahistoryofexposureto-damagingcytotoxic

chemotherapyand/orlarge-fieldradiationtherapy.

ICD-Ocoding

9920/3Myeloidneosmpostcytotoxictherapy

9987/3Myelodyssticneosmpostcytotoxictherapy

9920/3Myelodysstic/myeloproliferativeneosmpostcytotoxictherapy

9920/3Acutemyeloidleukaemiapostcytotoxictherapy

ICD-11coding

2A60.2YOtherspecifiedtherapy-relatedmyeloidneosms

Relatedterminology

Notrecommended:therapy-relatedmyeloidneosm;therapy-relatedmyelodysstic

neosm;therapy-relatedmyelodysstic/myeloproliferativeneosm;therapy-relatedacute

myeloidleukaemia.

Subtype(s)

Myelodyssticneosmpostcytotoxictherapy;myelodysstic/myeloproliferativeneosm

postcytotoxictherapy;acutemyeloidleukaemiapostcytotoxictherapy

Localization

Bloodandbonemarrowareprimarilyinvolved.Rarepresentationasmyeloidsarcomacan

occur{;}.

Clinicalfeatures

Mostpatientspresentwithpersistentcytopenias.TwoclinicalcategoriesofMN-pCThavebeen

recognized:casesfollowingexposuretoalkylatingagentsand/orionizingradiation(type1)and

casesfollowingexposuretotopoisomeraseIIinhibitors(type2).Thesehavedistinctiveclinical

presentationsandareassociatedwithparticulargeneticalterations(see#30675Table2.20).

However,mostpatientsreceivemultipletypesoftherapy,andtheboundariesweenthese

twocategoriesarethereforenotalwaysclear,becauseoftheiroverlappingfeatures.Recently