β受体阻滞剂降压地位.pptxVIP

β受体阻滞剂降压地位;报告提纲;?-阻滞剂：心血管领域重要的治疗药物;肾上腺髓质-----肾上腺素

交感神经末梢-----去甲肾上腺素;肾上腺素能受体亚型的分布与效应;肾上腺素能受体亚型的分布与效应;(PartialAgonistactivity);?-受体阻滞剂的可能降压机制;?-受体阻滞剂的分类;?-受体阻滞剂的药理学差异;?-阻滞剂的亲脂性和长期心脏保护

（一级预防试验）;?-阻滞剂的亲脂性和长期心脏保护

（二级预防试验）;心肌梗死后?-阻滞剂的长期治疗;部分?-阻滞剂的药理学特性;?-阻滞剂的降压疗效及地位

-MAPHY和STOP-H研究

-BPLTTC结果

-JNC-7概览

;?-受体阻滞剂：高血压治疗一线药物;倍他乐克降压的一级预防试验（MAPHY）;MAPHY：总死亡率曲线;;瑞典老年高血压试验（STOP-H）;STOP-H：主要终点和死亡率;;Contributingtrials;Newerbloodpressureloweringagentsversusplacebo

Moreintensiveversuslessintensivebloodpressureloweringregimens

Bloodpressureloweringregimensbasedondifferentdrugclasses

;Primaryoutcomes

Stroke

Coronaryheartdisease

Heartfailure(fatalorhospitalised)

Totalcardiovascularevents(compositeofallabove)

Cardiovascularmortality

Totalmortality;STROKE

Comparisonsofactivetreatmentsandcontrol;STROKE

Comparisonsofdifferentactivetreatments;CORONARYHEARTDISEASE

Comparisonsofactivetreatmentsandcontrol;CORONARYHEARTDISEASE

Comparisonsofdifferentactivetreatments;HEARTFAILURE

Comparisonsofactivetreatmentsandcontrol;HEARTFAILURE

Comparisonsofdifferentactivetreatments;MAJORCARDIOVASCULAREVENTS

Comparisonsofactivetreatmentsandcontrol;MAJORCARDIOVASCULAREVENTS

Comparisonsofdifferentactivetreatments;CARDIOVASCULARDEATH

Comparisonsofactivetreatmentsandcontrol;CARDIOVASCULARDEATH

Comparisonsofdifferentactivetreatments;TOTALMORTALITY

Comparisonsofactivetreatmentsandcontrol;TOTALMORTALITY

Comparisonsofdifferentactivetreatments;Similarneteffectsontotalcardio-

vasculareventsof:

Diuretics/beta-blockers

ACEinhibitors

Calciumantagonists

ARBsalsoeffectiveinreducingtotal

cardiovascularevents

;ACE-inhibitoranddiuretic/beta-blocker

basedregimensmoreeffectivethan

calciumantagonistsforpreventingheart