Acetoxycycloheximide-生命科学试剂-MCE.pdfVIP

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Acetoxycycloheximide

Cat.No.:HY-119420

CASNo.:2885-39-4

分⼦式:C₁₇H₂₅NO₆

分⼦量:339.38

作⽤靶点:Antibiotic;Apoptosis;Caspase;JNK;p38MAPK;TNF

Receptor;ERK;NF-κB;MitochondrialMetabolism

作⽤通路:Anti-infection;Apoptosis;MAPK/ERKPathway;StemCell/Wnt;

NF-κB;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Acetoxycycloheximide是⼀种具有抗肿瘤活性的抗⽣素。Acetoxycycloheximide是⼀种蛋⽩质合成抑制剂。

Acetoxycycloheximide通过激活JNK通路，显著诱导由线粒体释放的Cytochromec介导的procaspase-3的

活化和随后细胞凋亡(apoptosis)。Acetoxycycloheximide通过激活ERK和p38MAPK，触发细胞表⾯TNF-

R1的下调，从⽽阻⽌TNF-α激活NF-κB信号通路。Acetoxycycloheximide对雌性⼤⿏的毒性远⼤于雄性⼤

⿏。Acetoxycycloheximide可⽤于炎症和免疫疾病以及癌症的研究[1][2][3]。

IC50TargetProcaspase-3NF-κB

REFERENCES

[1].PALLOTTAAJ,etal.Toxicologyofacetoxycycloheximideasafunctionofsexandbodyweight.JPharmacolExpTher.1962

Jun;136:400-