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AcrB-IN-6

Cat.No.:HY-178111

CASNo.:3082621-32-4

分⼦式:C₂₈H₃₃BrN₂O₂

分⼦量:509.48

作⽤靶点:Bacterial

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AcrB-IN-6是⼀种有效的AcrB抑制剂。AcrB-IN-6能够抑制细菌多药外排泵的功能，从⽽显著增强多种抗⽣素

的抗菌活性。AcrB-IN-6在野⽣型⼤肠杆菌BW25113中可使最低抑菌浓度(MIC)降低32倍。AcrB-IN-6表现

出优异的协同抗菌作⽤、低细胞毒性和溶⾎性。AcrB-IN-6可⽤于研究细菌耐药性[1]。

体外研究AcrB-IN-6(Compound11i)(1-512μg/mL)doesnotshowanyantibacterialactivityagainstwild-typeE.coli

BW25113ortheBW25113ΔAcrBmutantbutdemonstratessynergisticactivitywithsixdistinctantibiotics

includedLinezolid(HY-10394),Oxacillin(HY-B0925A),Azithromycin(HY-17506),Erythromycin(HY-B0220),

Tetracycline(HY-A0107),Fusidicacid(HY-B1350),Minocycline(HY-17412A),Ampicillin(HY-B0522)and

Piperacillin(HY-B1923)[1].

AcrB-IN-6(50μM,0-5min)inhibitsNileRedactivityinwild-typeE.coliBW25113[1].

AcrB-IN-6(128μg/mL,0-20min)doesnotdisrupttheoutermembranepermeabilityandandinnermembrane

protonmotiveforceofthewild-typeE.coliBW25113[