MAO-A-B-IN-5-生命科学试剂-MCE.pdfVIP

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MAO-A/B-IN-5

Cat.No.:HY-178149

分⼦式:C₂₁H₂₀BrNOS

分⼦量:461.25

作⽤靶点:MonoamineOxidase

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MAO-A/B-IN-5是⼀种⼝服活性的MAO-A(IC50=73.88μM)和MAO-B(IC50=91.08μM)抑制剂。MAO-

A/B-IN-5逆转Sodiumnitroprusside(SNP)(HY-B0564)诱导的⼤脑脂质过氧化(IC50=130.2μM)和蛋⽩质羰

基化作⽤(IC50=229.8μM)。MAO-A/B-IN-5在⼩⿏中显⽰出剂量依赖和时间依赖的抗抑郁样疗效。MAO-

A/B-IN-5可⽤于抑郁症研究[1]。

IC50TargetMAO-AMAO-B

73.88μM(IC50)91.08μM(IC50)

体外研究MAO-A/B-IN-5(Compound3B)(25-200μM)significantlyinhibitscerebralMAO-AandMAO-Bactivitiesin

mousebraintissue,withIC50valuesof73.88μMforMAO-Aand91.08μMforMAO-B[1].

MAO-A/B-IN-5(100-500μM)reversessodiumnitroprusside(SNP)-inducedcerebrallipidperoxidation(IC50

=130.2μM)andproteincarbonylation(IC50=229.8μM)[1].

体内研究MAO-A/B-IN-5(Compound3B)(0.5-5mg/kg,i.g.,once)exertsantidepressant-likeeffectsintheTSTofmale

Swissmice[1].

MAO-A/B-IN-5(