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Apoptosisinducer50

Cat.No.:HY-179052

分⼦式:C₃₄H₂₄N₈O₆

分⼦量:640.6

作⽤靶点:Apoptosis;Autophagy;Bcl-2Family;Caspase;Atg8/LC3;

Atg7;CDK;ReactiveOxygenSpecies(ROS)

作⽤通路:Apoptosis;Autophagy;CellCycle/DNADamage;

Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Apoptosisinducer50(Compound5e)是⼀种凋亡(apoptosis)诱导剂，也是⼀种⾃噬(autophagy)诱导剂。

Apoptosisinducer50对三阴性乳腺癌细胞和转移性结肠癌细胞具有强效且选择性的抗癌活性。Apoptosis

inducer50上调了促凋亡蛋⽩(Bax、Bim、cleavedCaspase-9)的表达，下调抗凋亡蛋⽩(BCL-XL)的表达下调

。Apoptosisinducer50上调了⾃噬关键标志物如Beclin-1、ATG5的表达，增加了LC3-I向LC3-II的转化。

Apoptosisinducer50通过上调p21和p27的表达，下调CyclinD1，将癌细胞阻滞在G1/S期。Apoptosis

inducer50升⾼了ROS的⽔平。

IC50TargetBaxBimCaspase-9Bcl-xL

CDK1

REFERENCES

[1].DilekÖ,etal.Structure-activityoptimizationo