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APG-7

Cat.No.:HY-179036

分⼦式:C₃₀H₂₆O₁₂

分⼦量:578.52

作⽤靶点:Toll-likeReceptor(TLR)

作⽤通路:Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性APG-7与TLR4/MD-2界⾯结合，从⽽抑制NO的产⽣(IC50为24.2μg/mL)。APG-7是⼀种Apigenin(HY-

N1201)衍⽣物。APG-7对3T3成纤维细胞系的毒性较低。APG-7可⽤于氧化应激和炎症的研究。

IC50TargetTLR4

体外研究APG-7(25μg/mL)inhibitstheformationofsuperoxideanionwith29.06%inhibition[1].

APG-7(0.1-100μg/mL;48h)showednotoxicityat-25μg/mLonfibroblastcells[1].

In-silicoanti-canceractivityanalysisrevealsthatAPG-7displaysanti-canceractivityforB-lymphoblastic

cells,colonadenocarcinoma,non-smallcelllungcarcinoma,andmetastaticmelanoma[1].

CellProliferationAssay[1]

CellLine:3T3fibroblastcells

Concentration:100μg/mL,10μg/mL,1.0μg/mL,0.1μg/mL

IncubationTime:48h

Result:Moderatelysuppressedtheproductionoffreeradicals.Didnotshowtoxicityupto

concentrationof25μg/mL.

REFERENCES