Flt-3-IN-1-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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Flt-3-IN-1

Cat.No.:HY-178444

分⼦式:C₂₄H₂₃ClN₄O₃S

分⼦量:482.98

作⽤靶点:FLT3;Apoptosis

作⽤通路:ProteinTyrosineKinase/RTK;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Flt-3-IN-1是⼀种强效的FLT-3抑制剂，其IC50值为0.91μM。Flt-3-IN-1可导致⽩⾎病细胞G1期阻滞并诱

导细胞凋亡(apoptosis)。Flt-3-IN-1可⽤于癌症研究，如⽩⾎病研究[1]。

体外研究Flt-3-IN-1exhibitscytotoxicityagainstHL-60,CCRF-CEM,andMOLT-4leukemiacelllineswithIC50values

of0.13μM,7.50μM,and3.65μMrespectively[1].

Flt-3-IN-1(0.13μM,24h)arreststhecellcycleattheG1phaseandinduceapoptosisinHL-60cells[1].

CellCycleAnalysis[1]

CellLine:HL-60cells

Concentration:0.13μM

IncubationTime:24h

Result:IncreasedtheproportionofG1phasecellsto66.59%anddecreasedtheG2/Mphase

proportionto4.77%.

ApoptosisAnalysis[1]

CellLine:HL-60cells

Concentration:0.13μM

IncubationTime:24h

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