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PGK1-IN-1

Cat.No.:HY-178761

CASNo.:3093312-81-0

分⼦式:C₂₂H₂₈N₆O₃

分⼦量:424.5

作⽤靶点:PhosphoglycerateKinase(PGK)

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PGK1-IN-1(Compound6e)是⼀种强效且选择性的PGK1抑制剂(IC50：33nM)。PGK1-IN-1抑制PGK1介导

的糖酵解代谢，降低葡萄糖消耗/乳酸⽣成。PGK1-IN-1增强Nrf2的积累和HO-1的表达，并抑制炎症细胞因

⼦IL-1β和IL-6的转录和蛋⽩⽔平。PGK1-IN-1可改善葡聚糖硫酸钠(DSS)(HY-116282C)诱导的⼩⿏实验性

结肠炎。PGK1-IN-1可⽤于炎症性肠病(IBD)的研究。

IC50TargetPGK1

33nM(IC50)

REFERENCES

[1].HuangZ,etal.DiscoveryofNovelPurineDerivativesasPotentandOrallyBioavailablePGK1InhibitorsfortheTreatmentof

InflammatoryBowelDisease.JMedChem.2025Oct23;68(20):21394-21411.

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