Aminoflavone-NSC-686288-生命科学试剂-MCE.pdfVIP

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Aminoflavone

Cat.No.:HY-132974

CASNo.:165179-35-1

Synonyms:NSC-686288

分⼦式:C₁₆H₁₁F₃N₂O₂

分⼦量:320.27

作⽤靶点:ArylHydrocarbonReceptor;ReactiveOxygenSpecies(ROS);

DNAAlkylator/Crosslinker;DNA/RNASynthesis;Caspase;

Apoptosis;HIF/HIFProlyl-Hydroxylase

作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κ

B;CellCycle/DNADamage;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Aminoflavone是⼀种抗肿瘤剂。Aminoflavone通过激活AhR-miR-125b-2-3p轴抑制ITGA6/SOX2表达，从

⽽靶向乳腺癌⼲细胞。Aminoflavone诱导细胞内ROS升⾼，增加氧化DNA损伤标志物8-oxodG⽔平和

DNA-蛋⽩质交联。Aminoflavone引起S期阻滞，激活caspase-3/8/9并诱导凋亡(apoptosis)。

Aminoflavone以不依赖AhR的⽅式抑制HIF-1α表达。Aminoflavone可⽤于研究乳腺癌。

REFERENCES

[1].TerzuoliE,etal.Aminoflavone,aligandofthearylhydrocarbonreceptor,inhibitsHIF-1alphaexpressioninanAhR-independentfashion.

CancerRes.2010Sep1;70(17):68