ACT-1014-6470-生命科学试剂-MCE.pdfVIP

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ACT-1014-6470

Cat.No.:HY-157472

CASNo.:2363082-87-3

分⼦式:C₂₈H₂₉F₆N₅O

分⼦量:565.55

作⽤靶点:ComplementSystem

作⽤通路:Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性ACT-1014-6470是⼀种⼝服活性、强效、可逆且选择性的C5aR1拮抗剂。ACT-1014-6470能有效抑制C5aR1

的激活。ACT-1014-6470可⽤于炎症性疾病的研究。

REFERENCES

[1].SylvieFROIDEVAUX,etal.2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-onederivativesandrelatedcompoundsasc5areceptor

modulatorsfortreatingvasculitisandinflammatorydiseases.WO2019137927A1.WIPO(PCT).2019-01-09.

[2].OrtM,etal.First-in-humanstudywithACT-1014-6470,anoveloralcomplementfactor5areceptor1(C5aR1)antagonist,supportedby

pharmacokineticpredictionsfromanimalstopatients.BasicClinPharmacolToxicol.2022Aug;131(2):114-128.

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