AM-0883-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

AM-0883

Cat.No.:HY-179490

分⼦式:C₂₁H₂₁ClN₂O₃

分⼦量:384.86

作⽤靶点:TRPChannel

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AM-0883是⼀种TRPC6(瞬时受体电位经典6)激动剂(hTRPC6EC50=46nM)。AM-0083可⽤于⼼脏和肾脏

疾病的研究[1][2]。

IC50TargethTRPC6

46nM(EC50)

体外研究AM-0883canactivateHEK293TcellsWTTRPC6(EC50=45.5nM)andHEK293TN-terminaltruncation

mutantTRPC6(Δ2–72)(EC50=90.2nM)[1].

AM-0883functionallyactivatesthechannelthroughspecificresiduesattheS6/porehelixjunction[1].

AM-0883showsasignificantlystrongeractivatingeffectontheV867T/L868Tdoublemutantthanonthewild-

typechannel[1].

REFERENCES

[1].BaiY,etal.StructuralbasisforpharmacologicalmodulationoftheTRPC6channel.Elife.2020Mar9;9:e53311.

[2].ChubanovV,etal.Physiologicalfunctionsandphar