Aha1-Hsp90-IN-2-生命科学试剂-MCE.pdfVIP

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Aha1/Hsp90-IN-2

Cat.No.:HY-179377

分⼦式:C₂₁H₁₈F₃NO₄S

分⼦量:437.43

作⽤靶点:HSP;TauProtein

作⽤通路:CellCycle/DNADamage;MetabolicEnzyme/Protease;

NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Aha1/Hsp90-IN-2是⼀种选择性的Hsp90/Aha1相互作⽤抑制剂，其IC50为1.46μM。Aha1/Hsp90-IN-2通

过特异性阻断Hsp90与Aha1的结合，抑制Aha1介导的Hsp90ATP酶活性激活，从⽽减少tau蛋⽩聚集。

Aha1/Hsp90-IN-2可⽤于研究神经退⾏性疾病，如阿尔茨海默病。

REFERENCES

[1].KevinC,etal.OptimizationofHsp90/Aha1Small-MoleculeDisruptorsViatheEvaluationofAmideBioisosteres.2025Nov7.

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