AM-1430-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

AM-1430

Cat.No.:HY-115814

CASNo.:1975263-74-1

分⼦式:C₂₃H₁₉FN₈O

分⼦量:442.45

作⽤靶点:PI3K

作⽤通路:PI3K/Akt/mTOR

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AM-1430是⼀种⾼效、⾼选择性的、⼝服有效的PI3Kδ⼩分⼦抑制剂，其IC50为4.6nM。AM-1430对PI3K

α、PI3Kβ和PI3Kγ的IC50为14.18、2.2和3.22μM。AM-1430抑制B细胞增殖，在pAKT抑制模型和⾎

蓝蛋⽩(KLH)免疫反应模型均表现出卓越的体内活性。AM-1430可⽤于研究炎症和⾃⾝免疫性疾病。

IC50TargetPI3KδPI3KαPI3KβPI3Kγ

4.6nM(IC50)14.18μM(IC50)2.2μM(IC50)3.22μM(IC50)

REFERENCES

[1].Gonzalez-LopezdeTurisoF,etal.DiscoveryandinVivoEvaluationofthePotentandSelectivePI3KδInhibitors2-((1S)-1-((6-Amino-5-

cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide(AM-0687)and2-((1S)-1-((6-Amino-5-cyano-4-

pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide(AM-1430).JMedChem.2016Aug11;59(15):7252-67.

McePdfHeight