Amonafide-L-malate-AS-1413-L-malate-生命科学试剂-MCE.pdfVIP

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AmonafideL-malate

Cat.No.:HY-118823

CASNo.:618863-54-0

Synonyms:AS-1413L-malate

分⼦式:C₂₀H₂₃N₃O₇

分⼦量:417.41

作⽤靶点:Topoisomerase;DNAAlkylator/Crosslinker;Apoptosis

作⽤通路:CellCycle/DNADamage;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性AmonafideL-malate是⼀种拓扑异构酶II(topoisomeraseII)的抑制剂和DNA的嵌⼊剂。AmonafideL-

malate通过抑制TopoII与DNA的结合，来诱导凋亡(Apoptotic)信号通路的发⽣。TopoisomeraseInhibitor

IC50TargetTopoisomeraseII

客户使⽤本产品发表的科研⽂献

•ACSApplMaterInterfaces.2021Dec1;13(47):56519-56529.

•AnalChem.2022Mar22;94(11):4695-4702.

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REFERENCES

[1].AllenSL,etal.Amonafide:apotentialroleintreatingacutemyeloidleukemia.ExpertOpinInvestigDrugs.2011Jul;20(7):995-1003.

[2].AnderssonBS,etal.InvitrotoxicityandDNAcleavingcapacityofbenzisoquinolinedione(nafidimide;NSC308847)inhumanleukemia.

CancerRes.1987Feb15;47(4):1040-4.

[3].AjaniJA,etal.Invitroactivityofamonafideagainstprimaryhumantumorscomparedwiththeactivityofstandardagents.InvestNew

Drugs.1988Jun;6(2):79-85.

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