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CRBNligand-274

Cat.No.:HY-W952915

CASNo.:2925076-08-8

分⼦式:C₁₃H₁₂N₄O₂

分⼦量:256.27

作⽤靶点:LigandsforE3Ligase

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CRBNligand-274是⼀种E3泛素连接酶cereblon(CRBN)配体，⽤于募集cereblon蛋⽩。CRBNligand-274

可通过linker连接到靶蛋⽩配体上形成PROTAC。

IC50TargetCereblon

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand

theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

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