药学英语期末总结.docVIP

药学英语期末复习总结

上册p69TextBLeadCompounds先导化合物

什么是LeadCompounds?p69第一段

先导化合物的开发方法和代表药物(p71)

Fourtypes

i)Thefirststrategyconsistsofsystematicscreeningofsetsofcompoundsarbitrarilychosenfortheirdiversity,byselectedbiologicalassays.

代表药:newantibioticssuchasstreptomycin

ii)Thesecondstrategyisbasedonthemodificationandimprovementofexistingactivemolecules.

代表药:seriesoflovastatinanalogues

iii)Thethirdapproachresidesintheretroactiveexploitationofvariouspiecesofbiologicalinformationthatsometimesresultsfromnewdiscoveriesmadeinbiologyandmedicineandsometimesisjustthefruitsofmoreorlessserendipitousobservations.

代表药：nitroglycerol,penicilliumnotaum,sildenafil

iv)Thefourthroutetonewactivecompoundsisarationaldesignbasedontheknowledgeofthemolecularcauseofthepathologicaldysfunction.

代表药：captopril

Word

captopriln.卡托普利，甲巯丙脯酸

cimetidinen.西咪替丁（抗消化性溃疡药）

retroactiveadj.反动的，追溯的，有追溯力的

nitroglyceroln.硝酸甘油

上册p94Biopharmaceutics生物药剂学

BA（生物利用度,bioavailability）

Thefractionofanadministereddoseofdrugthatreachesthesystemiccirculationinunchangedformisknownasthebioavailabledose.Therelativeamountofanadministereddoseofaparticulardrugwhichreachesthesystemiccirculationandrateatwhichthisoccursisknownasbioavailabilityofthatdrug.(p95第一段第三行至第六行)

Itshouldalsobenotedthatinthecontextofbioavailability,thetermsystemiccirculationrefersprimarilytovenousblood(excluding除了thehepaticportalbloodduringtheabsorptionphase)andarterialbloodwhichcarriestheintactdrugtothetissues.(p95第二段最后一句话)

临床效果与血药浓度关系

Ithasbeenassumedthattheplasmadrugconcentrationisdirectlyproportionaltotheclinicaleffectofthatdrug.(p94第二段最后一句话)

生物制剂的特点（没找到o(︶︿︶)o唉）

Word

arterialadj.动脉的

capsulen.胶囊剂

coadminisitrationn.一起服用

dissolutionn.分解，溶化

hepaticadj.肝的

intramuscularadj.肌肉的

pro-drugn.前药

suspensionn.悬浮（液）

systemi