CRBN-ligand-719-生命科学试剂-MCE.pdfVIP

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CRBNligand-719

Cat.No.:HY-W953611

CASNo.:2925095-85-6

分⼦式:C₁₃H₁₂N₄O₃

分⼦量:272.26

作⽤靶点:LigandsforE3Ligase

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CRBNligand-719是⼀种E3泛素连接酶cereblon(CRBN)配体，⽤于募集cereblon蛋⽩。CRBNligand-719

可通过linker连接到靶蛋⽩配体上形成PROTAC。

IC50TargetCereblon

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand

theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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